Influenza vaccine formulations for intradermal delivery

Details Influenza vaccine formulations for intradermal delivery Influenza vaccine formulations for intradermal delivery

A - Human Necessities

61

K

A61K 39/145 (2006.01) C12N 7/04 (2006.01)

Patent

CA 2438942

The invention relates to the use of a trivalent, non-live influenza antigen preparation, particularly a split influenza preparation, in the manufacture of a one-dose influenza vaccine for intradermal delivery. In particular the invention relates to the use of spilt influenza preparations wherein the vaccine comprises at least one non-ionic surfactant selected from the group consisting of the octyl- or nonylphenoxy polyoxyethanols (for example the commercially available TritonTM series), polyoxyethylene sorbitan esters (TweenTM series) and polyoxyethylene ethers or esters of general formula (I): HO(CH2CH2O)n-A-R wherein n is 1-50, A is a bond or-C(O)-,R is C1-50 alkyl or phenyl C1-50 alkyl; and combinations of two or more of these.

L'invention concerne l'utilisation d'une préparation trivalente et non vivante d'antigène contre la grippe, notamment une préparation antigrippale sous-unitaire, dans la production d'un vaccin antigrippal monodose en administration intradermique. L'invention concerne en particulier l'utilisation de préparations antigrippales sous-unitaires, le vaccin comprenant au moins un tensioactif non ionique sélectionné dans le groupe constitué par les polyoxyéthanols octylphenoxy ou nonylphenoxy (par exemple, la série Triton?TM¿ vendue dans le commerce), les esters de sorbitan polyoxyéthyléniques (série Tween?TM¿) et les éthers ou esters polyoxyéthyléniques de formule générale (I): HO(CH¿2?CH¿2?O)¿n?-A-R, dans laquelle n est 1-50, A représente une liaison ou -C(O)-, R signifie alkyle C¿1-50 ? ou phényle C¿1-50? alkyle; ainsi que des combinaisons de deux de ces éléments ou plus.

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