Breast specific genes and proteins

Details Breast specific genes and proteins Breast specific genes and proteins

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 38/45 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/40 (2006.01) C12N 9/10 (2006.01) C12N 15/54 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2225824

Human breast specific gene polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides or polypeptides as a diagnostic marker for breast cancer and as an agent to determine if breast cancer has metastasized. Also disclosed are antibodies specific to the breast specific gene polypeptides which may be used to target cancer cells and be used as part of a breast cancer vaccine. Methods of screening for antagonists for the polypeptide and therapeutic uses thereof are also disclosed.

L'invention concerne des polypeptides de gènes humains spécifiques au sein, l'ADN (ARN) les codant et un procédé de production desdits polypeptides par des techniques de recombinaison. Elle porte aussi sur des procédés d'utilisation desdits polynucléotides ou polypeptides en tant que marqueur diagnostique pour le cancer du sein et en tant qu'agent pour déterminer si le cancer du sein a métastasé. Elle se rapporte encore à des anticorps spécifiques aux polypeptides de gènes spécifiques au sein, qui peuvent être utilisés pour cibler des cellules cancéreuses et en tant que partie d'un vaccin contre le cancer du sein, ainsi qu'à des procédés de criblage d'antagonistes du polypeptides et à leurs utilisations thérapeutiques.

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