Novel assay for the detection of an antibody bound to a cell...

G - Physics – 01 – N

Patent

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Details

G01N 33/543 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2642634

This invention relates to the design of a novel immunoassay specific for the measurement of humanized antibody, Campath-1H, bound to the CD52 cell membrane receptor. The method can be used for pharmacokinetic studies and for monitoring purposes. The invention reveals improvements in higher specificities and sensitivities that can be obtained in relation to the conventionally used methods.

La présente invention concerne la conception d'un nouveau dosage immunologique spécifique à la mesure d'un anticorps humanisé, Campath-1H, lié au récepteur de membrane cellulaire CD52. Le procédé peut être utilisé pour des études pharmacocinétiques et à des fins de suivi. L'invention réalise des améliorations qui donnent des spécificités et des sensibilités supérieures par rapport à ce qui peut être obtenu avec les procédés utilisés traditionnellement.

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