Methods and compositions for antibody therapy

Details Methods and compositions for antibody therapy Methods and compositions for antibody therapy

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 39/395 (2006.01) C07K 16/30 (2006.01)

Patent

CA 2650730

Methods and materials are provided for determining the responsiveness of a subject to a therapy, such as an antibody therapy and for selecting and/or for treating a subject based on a Fc.gamma.RIIA polymorphism, or a Fc.gamma.RIIIA polymorphism, or both an Fc.gamma.RIIA polymorphism and a Fc.gamma.RIIIA polymorphism, including where the treatment is an therapy, such as rituximab. Methods and materials are also provided for designing, making, screening, testing and/or administering antibodies as well as for optimizing antibody therapies based upon a subject's Fc.gamma.RIIA polymorphism, or Fc.gamma.RIIIA polymorphism, or both the Fc.gamma.RIIA polymorphism and the Fc.gamma.RIIIA polymorphism.

L'invention concerne des procédés et des matériaux permettant de déterminer la réactivité d'un sujet à une thérapie, telle qu'une thérapie par anticorps, et de sélectionner et/ou de traiter un sujet sur la base d'un polymorphisme Fc.gamma.RIIA ou d'un polymorphisme Fc.gamma.RIIIA ou à la fois d'un polymorphisme Fc.gamma.RIIA et d'un polymorphisme Fc.gamma.RIIIA, y compris lorsque le traitement est une thérapie, par exemple au rituximab. L'invention concerne également des procédés et des matériaux permettant de concevoir, produire, cribler, tester et/ou administrer des anticorps ainsi que d'optimiser des thérapies par anticorps basées sur le polymorphisme Fc.gamma.RIIA ou sur le polymorphisme Fc.gamma.RIIIA ou à la fois sur le polymorphisme Fc.gamma.RIIA et le polymorphisme Fc.gamma.RIIIA d'un sujet.

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