C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/46 (2006.01) A61K 31/426 (2006.01) A61K 31/428 (2006.01) A61P 25/28 (2006.01) C07D 277/82 (2006.01)
Patent
CA 2562123
The present invention relates to compounds of the Formula (I) wherein R1, R3, R4, R5, R6 and R7 are as defined. Compounds of the Formula (I) have activity inhibiting production of A.szlig.-peptide. The invention also relates to pharmaceutical compositions and methods of treating disorders and diseases, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula (I).
La présente invention a trait à des composés de formule (I) dans laquelle : R?1¿, R?3¿, R?4¿, R?5¿, R?6¿ et R?7¿ sont tels que définis dans la description. Les composés de formule (I) présentent une activité inhibitrice de la production du peptide A.beta.. L'invention a également trait à des compositions pharmaceutiques et à des composés pour le traitement de troubles et de maladies, par exemple, des troubles neurodégénératifs et/ou neurologiques, tels que la maladie d'Alzheimer, chez un mammifère comportant des composés de formule (I).
Chen Yuhpyng Liang
Zhang Lei
Pfizer Products Inc.
Smart & Biggar
LandOfFree
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