C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/53 (2006.01) A61K 38/44 (2006.01) C07K 16/40 (2006.01) C12N 1/21 (2006.01) C12N 9/02 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2269647
The present invention provides a human squalene epoxidase (HSQEP) and polynucleotides which identify and encode HSQEP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HSQEP and a method for producing HSQEP. The invention also provides for the use of HSQEP and agonists, antibodies, or antagonists specifically binding HSQEP, in the prevention and treatment of diseases associated with expression of HSQEP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HSQEP for the treatment of diseases associated with the expression of HSQEP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HSQEP.
La présente invention concerne une squalène époxydase humaine (HSQEP) et des polynucléotides qui identifient et codent cette HSQEP. L'invention concerne également des vecteurs d'expression et des cellules hôtes obtenues par génie génétique, comprenant les séquences nucléotidiques codant la HSQEP ainsi qu'un procédé de production de HSQEP. L'invention concerne en outre l'utilisation de HSQEP et d'agonistes, d'anticorps, ou d'antagonistes fixant spécifiquement la HSQEP, pour la prévention et le traitement de maladies associées à l'expression de la HSQEP. De plus, l'invention concerne l'utilisation de molécules antisens agissant contre les polynucléotides codant la HSQEP pour le traitement de maladies associées à l'expression de la HSQEP. Sont également décrits des dosages faisant appel auxdits polynucléotides, ou à des fragments ou aux compléments de ceux-ci, et à des anticorps fixant spécifiquement la HSQEP.
Hawkins Phillip R.
Hillman Jennifer L.
Incyte Genomics Inc.
Incyte Pharmaceuticals Inc.
Smart & Biggar
LandOfFree
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