C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 7/10 (2006.01) C07H 19/06 (2006.01)
Patent
CA 2723702
The present invention relates to a process for preparing a compound of formula 682-4, said process comprising the steps of. (i) converting a compound of formula 682-1 into a compound of formula 682-2'; (ii) converting said compound of formula 682-2' into a compound of formula 682-3; and (iii) converting said compound of formula 682-3 into a compound of formula 682-4. Further aspects of the invention relate to the use of the above process in the preparation of 2'-cyano-2'-deoxy-N4 -palmitoyl-1-.beta.-D-arabmofuranosylcytosine, a pyrimidine nucleoside which is therapeutically useful in the treatment and/or prevention of cancer.
La présente invention porte sur un procédé de préparation d'un composé de formule (682-4). Ce procédé comprend les étapes consistant à : (i) convertir un composé de formule (682-1) en un composé de formule (682-2'); (ii) convertir ledit composé de formule (682-2') en un composé de formule (682-3); et (iii) convertir ledit composé de formule (682-3) en un composé de formule (682-4). D'autres aspects de l'invention portent sur l'utilisation du procédé ci-dessus dans la préparation de la 2'-cyano-2'-désoxy-N4-palmitoyl-1-ß-D-arabinofuranosylcytosine, un nucléoside pyrimidique qui est thérapeutiquement utile dans le traitement et/ou la prévention du cancer.
Westwood Robert
Wood Gavin Jeffrey
Cyclacel Limited
Sim & Mcburney
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