Monoclonal antibodies specific for beta-amyloid

Details Monoclonal antibodies specific for beta-amyloid Monoclonal antibodies specific for beta-amyloid

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) A61K 39/395 (2006.01) C07K 16/18 (2006.01) C12N 5/00 (2006.01) C12N 5/12 (2006.01) C12P 21/00 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2504349

This invention provides methods and compositions for the detection, diagnosis and treatment of amyloid-associated diseases, in particular, diseases comprising deposition of amyloid assemblies, fibrils, filaments, tangles, or plaques. A preferred composition comprises monoclonal antibodies that specifically bind amyloid proteins, peptides or fragments and change the conformation.

L'invention concerne des méthodes et des compositions permettant de détecter, diagnostiquer et traiter des maladies associées à un amyloïde, notamment, des maladies impliquant un dépôt d'ensembles, de fibrilles, de filaments, d'enchevêtrements ou de plaques amyloïdes. Une composition préférée comprend des anticorps monoclonaux qui se lient spécifiquement à des protéines, des peptides ou des fragments amyloïdes et modifient leur conformation.

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