Soluble prodrugs of paclitaxel

Details Soluble prodrugs of paclitaxel Soluble prodrugs of paclitaxel

C - Chemistry, Metallurgy

07

D

C07D 405/02 (2006.01) A61K 31/44 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2294606

Novel 2'-onium salts of paclitaxel act as prodrugs in mammalian patients to yield paclitaxel in vivo. Methods of synthesizing these onium salts are disclosed, as are methods of treating patients suffering from paclitaxel- responsive diseases by administering effective amounts of the onium salts and pharmaceutical compositions containing the novel salts which are suitable for administration to patients requiring paclitaxel therapy.

L'invention concerne de nouveaux sels 2'-onium de paclitaxel servant de bioprécurseurs chez les patients mammifères pour produire du paclitaxel in vivo. L'invention concerne également des procédés d'obtention par synthèse de ces sels onium, ainsi que des procédés de traitement de patients atteints de maladies réagissant au paclitaxel, consistant à administrer des quantités suffisantes de sels onium. L'invention concerne en outre des compositions pharmaceutiques renfermant ces nouveaux sels, qui sont adaptées pour être administrées aux patients nécessitant une thérapie au paclitaxel.

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