Peptidoglycan biosynthetic gene mura from streptococcus...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/54 (2006.01) C12N 9/10 (2006.01) C12Q 1/48 (2006.01)

Patent

CA 2262413

The invention provides isolated nucleic acid compounds encoding the stem peptide biosynthetic gene murA of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host cells for expressing the MurA enzyme product and a method for identifying compounds that inhibit stem peptide biosynthesis.

Composés d'acide nucléique isolés codant le gène biosynthétique de pentapeptide murA du Streptoccucus pneumoniae. Des vecteurs et des cellules hôtes hétérologues transformées destinés à exprimer le produit enzymatique Mur A sont également décrits, ainsi qu'un procédé d'identification de composés qui inhibent la biosynthèse de peptides souches.

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