Process to prepare and isolate geldanamycin

Details Process to prepare and isolate geldanamycin Process to prepare and isolate geldanamycin

C - Chemistry, Metallurgy

12

P

C12P 17/10 (2006.01) C07D 225/06 (2006.01)

Patent

CA 2476658

The present invention relates to a process of preparing geldanamycin by culturing Streptomyces hygroscopicus in an aqueous nutrient medium. The aqueous nutrient medium can comprise starch, a starch conversion enzyme, an assimilable source of protein and optionally a further assimilable source of carbon or can comprise an assimilable source of carbon and an assimilable source of protein. The present invention also relates to a process for the isolation and purification of geldanamycin.

L'invention concerne un processus pour préparer et isoler la geldanamycine par la culture de <i>Streptomyces</i> <i>hygroscopicus</i> dans un milieu d'éléments nutritifs aqueux. Le milieu d'éléments nutritifs aqueux peut comprendre de l'amidon, une enzyme stabilisatrice d'amidon, une source assimilable de protéines et éventuellement une deuxième source assimilable de carbone ou comprendre une source assimilable de carbone et une source assimilable de protéines. La présente invention concerne aussi un procédé pour isoler et purifier la geldanamycine.

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