Proteases for pharmaceutical use

Details Proteases for pharmaceutical use Proteases for pharmaceutical use

A - Human Necessities

61

K

A61K 38/48 (2006.01) A61K 38/54 (2006.01) C12N 9/54 (2006.01)

Patent

CA 2612806

The pharmaceutical use of proteases related to amino acids 1-274 of SEQ ID NO: 2, the serine protease derived from Bacillus licheniformis, which is also designated subtilisin Carlsberg, optionally in combination with a lipase and/or an amylase. Examples of medical indications are: Treatment of digestive disorders, pancreatic exocrine insufficiency (PEI), pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II.

L'invention concerne l'utilisation pharmaceutique de protéases associées à des acides aminés 1-274 de SEQ ID NO: 2, à la sérine protéase dérivée de Bacillus licheniformis, qui est également appelée subtilisine Carlsberg, éventuellement en combinaison avec une lipase et/ou une amylase. Comme exemples d'indications médicales, on trouve : le traitement de troubles digestifs, de l'insuffisance pancréatique exocrine (IPE), de la pancréatite, de la fibrose kystique, du diabète de type I, et/ou du diabète de type II.

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