Transdermal device for administration through...

A - Human Necessities – 61 – K

Patent

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A61K 9/70 (2006.01)

Patent

CA 2189993

A transdermal device is described suitable for delivery of a pharmaceutical to the systemic circulation through de-epithelialized skin. In its various embodiments the device includes means to prevent the attack of any protein or polypeptide active agent included therein by proteolytic enzymes which exude from the lesion, means to prevent the ingress of bacteria and other cellular debris from the lesion and means to ensure that substantially all said active agent is directed to the de-epithelialized lesion.

Dispositif transdermique conçu pour apporter un médicament à la circulation générale à travers une peau dépourvue d'épithélium. Dans ses divers modes de réalisation, ce dispositif comprend des moyens destinés à empêcher l'attaque d'un quelconque agent actif polypeptidique ou protéique contenu dans ce dispositif par des enzymes protéolytiques exsudant de la lésion, des moyens destinés à empêcher l'entrée de bactéries et autres débris cellulaires provenant de la lésion, ainsi que des moyens permettant que sensiblement tout l'agent actif soit dirigé sur la lésion dépourvue d'épithélium.

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