Novel antibiotic rk-1061s and a method of production thereof

Details Novel antibiotic rk-1061s and a method of production thereof Novel antibiotic rk-1061s and a method of production thereof

C - Chemistry, Metallurgy

12

N

C12N 1/20 (2006.01) C07H 19/06 (2006.01) C12P 17/16 (2006.01) C12P 19/38 (2006.01)

Patent

CA 2252483

Antibiotics RK-1061 having a novel chemical structure and a process for preparing the same. They have a structural formula represented by general formula (I) wherein A represents R1 or R1CH(OR2)CH2, R2 represents a 3- methylglutaric acid residue and R3 represents a sulfate group or a hydrogen atom. The process comprises culturing a ray fungus belonging to the genus Streptomyces and isolating RK-1061 from the culture. Streptomyces sp.SN-1061M (FERM BP-5800) is capable of stably producing RK-1061 at a high productivity.

Cette invention se rapporte à des antibiotiques RK-1061 ayant une nouvelle structure chimique et à un procédé pour leur préparation. Ces antibiotiques ont une formule structurale représentée par la formule générale suivante (I), où A représente R¿1? ou R¿1?CH(OR¿2?)CH¿2?, R¿2? représente un reste d'acide 3-méthylglutarique et R¿3? représente un groupe sulfate ou un atome d'hydrogène. Le procédé de cette invention consiste à cultiver un champignon Actinomyces appartenant au genre Streptomyces et à isoler l'antibiotique RK-1061 de cette culture. Les Streptomyces de l'espèce SN-1061M (FERM BP-5800) sont capables de produire de façon stable l'antibiotique RK-1061 avec une productivité élevée.

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