17-alkylketone steroids useful as 5-.alpha.-reductase...

Details 17-alkylketone steroids useful as 5-.alpha.-reductase... 17-alkylketone steroids useful as 5-.alpha.-reductase...

C - Chemistry, Metallurgy

07

J

C07J 7/00 (2006.01) A61K 31/56 (2006.01) A61K 31/57 (2006.01) A61K 31/575 (2006.01) C07J 3/00 (2006.01) C07J 9/00 (2006.01) C07J 31/00 (2006.01) C07J 41/00 (2006.01)

Patent

CA 2138956

Invented are 17.alpha. and 17.beta.-alkylketone-3-carboxy aromatic A ring analogues of steroidal synthetic compounds, pharma- ceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5-.alpha.-reductase iso- zyme 1 and steroid 5-.alpha.-reductase isozyme 2. Also invented are intermediates and processes used in preparing these compounds.

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