Method of mass spectrometry

Details Method of mass spectrometry Method of mass spectrometry

G - Physics

01

N

G01N 33/68 (2006.01) C07J 1/00 (2006.01) G01N 27/62 (2006.01) G01N 30/72 (2006.01) G01N 33/48 (2006.01) H01J 49/26 (2006.01) B01J 19/00 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2482095

A method of identifying post-translationally modified proteins is disclosed. The method comprises mass analysing peptide ions and then subtracting from the determined mass of the peptide ion the known increase in mass due to one or more modifications of interest. The resulting value which represents the mass a peptide would have, had the protein from which it is derived hot been modified, is then used to search against a peptide databank. A short list of possible peptides is formed by selecting peptides which have both the right mass or mass to charge ratio (to within a user specified tolerance) and which also support at least one of the user selected modifications of interest. Each short listed peptide is then scored in turn against fragmentation data related to the experimentally observed peptide.

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