Method for induction and enhancement of apoptosis in tumor...

A - Human Necessities – 61 – K

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A61K 38/08 (2006.01)

Patent

CA 2614532

The present invention relates to methods for inducing and enhancing apoptosis in pathogenic cells. In particular, the present invention relates to the use of GnRH II antagonists for inducing and enhancing apoptosis of specific types of tumor cells, i.e. breast cancer and malignant melanoma as well as gynaecological cancers like endometrial or ovarian cancer, expressing the GnRH II receptor as well as to methods relating thereto. In addition, new GnRH II antagonists are provided.

La présente invention concerne des méthodes pouvant induire et accélérer l'apoptose dans des cellules pathogènes. L'invention concerne en particulier l'utilisation d'antagonistes du GnRH II pour induire et accélérer l'apoptose de types spécifiques de cellules cancéreuses, c'est-à-dire le cancer du sein et le mélanome malin, ainsi que les cancers gynécologiques tels que le cancer de l'endomètre ou le cancer de l'ovaire, exprimant le récepteur du GnRH II, ainsi que des méthodes associées. On décrit en outre de nouveaux antagonistes du GnRH II.

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