Oral compositions containing ondansetron

A - Human Necessities – 61 – K

Patent

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A61K 31/415 (2006.01)

Patent

CA 2205546

The invention relates to a liquid composition for oral administration comprising ondansetron or a pharmaceutically acceptable derivative thereof, a sweetener and one or more pharmaceutically acceptable excipients, characterised in that the sweetener comprises one or more polyhydric alcohols and the pH of the composition lies in the range 2.0 to 5Ø Methods for the manufacture of such compositions and for their use in the treatment of conditions mediated through the action of 5-hydroxytryptamine (5HT) at 5HT3 receptors are also described.

Composition liquide à administrer par voie orale comprenant de l'ondansétron ou un dérivé acceptable sur le plan pharmaceutique de ce produit, un édulcorant et un ou plusieurs excipients acceptables sur le plan pharmaceutique, caractérisé par le fait que l'édulcorant comprend un ou plusieurs polyols et que le pH de la composition se situe entre 2,0 et 5,0. Les procédés de fabrication des composés de ce type et leur utilisation pour le traitement d'affections pour lesquelles on recourt à l'action de la 5-hydroxytryptamine (5HT) sur les récepteurs 5HT¿3? sont également présentés.

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