Thiazole sulfonamide compounds for the treatment of...

C - Chemistry – Metallurgy – 07 – D

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C07D 277/28 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) C07D 277/30 (2006.01) C07D 277/64 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2561928

The present invention relates to compounds of the Formula (I) wherein R1, R2, R3, R4, m, n and p are as defined. Compounds of the Formula (I) have activity inhibiting production of A.beta.-peptide. The invention also relates to pharmaceutical compositions and methods for treating diseases, for example, neurodegenerative diseases, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula (I).

La présente invention concerne des composés représentés par la formule (I) dans laquelle R1, R2, R3, R4, m, n et p sont tels que définis. Les composés représentés par la formule (I) présentent une activité d'inhibition de la production du peptide A.beta.. Cette invention se rapporte également à des compositions pharmaceutiques et à des méthodes de traitement des maladies telles que les maladies neurodégénératives comme par exemple la maladie d'Alzheimer, chez un mammifère, ces méthodes de traitement comprenant l'administration de composés représentés par la formule (I). Formule (I)

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