Hemoglobin-hydroxyethyl starch complexes

Details Hemoglobin-hydroxyethyl starch complexes Hemoglobin-hydroxyethyl starch complexes

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 38/42 (2006.01) C08B 31/00 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2233725

Hemoglobin conjugates useful as a hemoglobin-based oxygen carrier are prepared by reacting hemoglobin with oxidized hydroxyethyl starch, and allowing the resultant conjugate to degrade to a lower molecular weight product, after conjugation. The conjugate is then reductively stabilized to form secondary amino bonds between the hemoglobin and the hydroxyethyl starch, and formulated as an HBOC.

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