Method for generation and use of stable isotope patterns in...

G - Physics – 01 – N

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G01N 30/06 (2006.01) G01N 30/72 (2006.01)

Patent

CA 2702848

A composition adapted for mass spectral analysis is disclosed as are methods of its use in mass spectral analyses. A contemplated composition contains a mass spectrally-determinable amount of each of (i) at least one analyte to be assayed and (ii) a standard compound. Each of the molecules of the standard compound contains one or the other of a pair of two stable isotopes of the same element that differ in molecular weight by at least two atomic mass units. Those two isotopes are present in the molecules of the standard compound in a predetermined ratio that is other than the naturally occurring ratio of those isotopes.

L'invention concerne une composition adaptée à l'analyse spectrale de masse ainsi que ses procédés d'utilisation dans les analyses spectrales de masse. Une composition envisagée contient une quantité de masse déterminable spectralement de chacun (i) d'au moins un analyte devant être testé et (ii) d'un composé standard. Chacune des molécules du composé standard contient l'une ou l'autre d'une paire de deux isotopes stables du même élément qui diffèrent de par leur poids moléculaire d'au moins deux unités de masse atomique. Ces deux isotopes sont présents dans les molécules du composé standard selon un rapport prédéterminé qui est différent du rapport naturel de ces isotopes.

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