Ligands that enhance endogenous compounds

Details Ligands that enhance endogenous compounds Ligands that enhance endogenous compounds

A - Human Necessities

61

K

A61K 39/395 (2006.01)

Patent

CA 2587206

The invention relates to ligands that comprise a moiety (e.g., a dAb) that has a binding site with binding specificity for an endogenous target compound but do not substantially inhibit the activity of said endogenous target compound. Preferably, the ligand does not bind to the active site of an endogenous target compound. The invention relates to the use of such a ligand for the manufacture of a medicament for increasing the half-life, bioavailability, activity or amount of an endogenous target compound to which the ligand binds.

L'invention se rapporte à des ligands qui comprennent une fraction (par ex. : dAb) comportant un site de liaison présentant une spécificité de liaison pour un composé endogène cible, mais qui n'inhibent sensiblement pas l'activité de ce composé endogène cible. De préférence, le ligand ne se lie pas au site actif d'un composé endogène cible. Cette invention concerne en outre l'utilisation d'un tel ligand pour produire un médicament servant à augmenter la demi-vie, la biodisponibilité, l'activité, ou la quantité d'un composé endogène cible auquel le ligand se lie.

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