Benzoquinazoline derivatives

Details Benzoquinazoline derivatives Benzoquinazoline derivatives

C - Chemistry, Metallurgy

07

D

C07D 405/06 (2006.01) A61K 31/517 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01) C07D 239/74 (2006.01) C07D 413/06 (2006.01)

Patent

CA 2674921

A compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein -R represents a group of two fused rings -A-B wherein A is optionally substituted heteroaryl or aryl and B is a saturated or unsaturated 4, 5, 6 or 7 membered ring optionally containing one or more heteroatoms selected from O, N and S; the optional substituents on R being one or more groups independently selected from oxo, cyano, halo or further optionally substituted C1-C6 alkyl, C2-C6 alkenyl, C1-C6 alkoxy, amino; the further optional substituents being selected from cyano, halo, C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkoxy, amino; for promoting the release of parathyroid hormone; for preventing or treating bone conditions which are associated with increased calcium depletion or resorption or in which stimulation of bone formation and calcium fixation in the bone is desirable.

L'invention porte sur un composé représenté par la formule (I) ou sur un sel ou un ester pro-médicament de qualité pharmaceutique de celui-ci. Dans la formule, R est tel que défini dans la description.

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