Synergism of tnf and il-4

Details Synergism of tnf and il-4 Synergism of tnf and il-4

A - Human Necessities

61

K

A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 38/21 (2006.01)

Patent

CA 2092914

A composition of matter which comprises Tumor Necrosis Factor (TNF) and Interleukin-4 (IL-4) has been disclosed, This composition inhibited the growth of human breast cancer cells, human vulvar carcinoma cells and human histiocytic lymphoma cells a dose-dependent manner. The growth characteristics of human breast cancer cells were minimally affected when exposed to TNF or IL-4 alone. However, the combination of these two cytokines together inhibited the growth of these cells in a dose-de- pendent manner. Additionally, interferon-gamma (IFN-g) caused a further potentiation of the antiproliferative effects of the TNF and IL-4 composition.

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