Techniques for identifying molecular structures and treating...

A - Human Necessities – 61 – B

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A61B 5/00 (2006.01) A61K 41/00 (2006.01) A61K 49/00 (2006.01)

Patent

CA 2494231

Techniques for detecting fluorescence emitted by molecular constituents in a wall of a body lumen include introducing an autonomous solid support into the body lumen. Cells in a lumen wall of the body lumen are illuminated by a light source mounted to the solid support with a wavelength that excites a particular fluorescent signal. A detector mounted to the solid support detects whether illuminated cells emit the particular fluorescent signal. If the particular fluorescent signal is detected from the illuminated cells, then intensity or position in the lumen wall of the detected fluorescent signal, or both, is determined. These techniques allow the information collected by the capsule to support diagnosis and therapy of GI cancer and other intestinal pathologies and syndromes. For example, these techniques allow diagnostic imaging using endogenous and exogenous fluoroprobes, treating diseased sites by targeted release of drug with or without photoactivation, and determining therapeutic efficacy.

L'invention concerne des techniques destinées à détecter la fluorescence émise par des constituants moléculaires dans une paroi d'une lumière corporelle consistant à introduire un support solide autonome dans la lumière corporelle. Des cellules se trouvant dans une paroi lumineuse de la lumière corporelle sont récupérées par une source de lumière montée sur le support solide avec une longueur d'onde qui dope un signal fluorescent particulier. Si le signal fluorescent particulier détecté par les cellules éclairées, l'intensité ou la position de la paroi lumineuse du signal fluorescent détecté, ou les deux, sont déterminés. Grâce à ces techniques, les informations collectées par la capsule permettent de supporter le diagnostic et le traitement du cancer gastro-intestinal ainsi que d'autres pathologies et syndromes intestinaux. Ces techniques permettent par exemple l'imagerie diagnostique à l'aide de sondes fluorescentes exogène et endogène, le traitement de sites infectés par libération ciblée d'un médicament avec ou sans photo-activation, et la détermination de l'efficacité du traitement.

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