New vitamin d derivatives with cyclic substructures in the...

C - Chemistry – Metallurgy – 07 – C

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Details

C07C 401/00 (2006.01) C07D 235/12 (2006.01) C07D 263/32 (2006.01) C07D 277/24 (2006.01) C07D 307/80 (2006.01) C07D 333/16 (2006.01) C07D 333/22 (2006.01)

Patent

CA 2376465

The invention relates to vitamin D derivatives of the formula (I), wherein Z is an optionally substituted carbocyclic or heterocyclic, optionally aromatic or heteroaromatic 5- or 6-membered ring or an optionally substituted condensed ring structure that consists of a 5-membered and a 6-membered ring or of two 6- membered rings, and Q, R1-R4, X1-X2 and Y1-Y3 have the meanings given in the description. The invention further relates to a method for their production, to the use of said derivatives in the preparation of medicaments, and to a method for producing compounds of the formula (Iia), wherein E represents any side chain, and R7, R8, Y2, Y3 and Y5 have the meanings given in the description. The invention also relates to the intermediates of both methods.

L'invention concerne les dérivés de vitamine D de la formule (I), le procédé de fabrication desdits dérivés, les produits intermédiaires de ce procédé, ainsi que l'utilisation dans la préparation de produits pharmaceutiques.

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