Multi-component vaccine comprising at least two antigens...

Details Multi-component vaccine comprising at least two antigens... Multi-component vaccine comprising at least two antigens...

A - Human Necessities

61

K

A61K 39/102 (2006.01) A61K 39/116 (2006.01) A61K 39/295 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2355466

A multi-component immunogenic composition confers protection on an immunized host against infection caused by Haemophilus influenzae. Such composition comprises at least two different antigens of Haemophilus influenzae, one of which is an adhesin. High molecular weight (HMW) proteins of non-typeable Haemophilus influenzae enhance the immune response in a host to a non-proteolytic analog of Hin47 protein in such immunogenic compositions with one component not impairing the immunogenicity of the other. The Haemophilus vaccine may be combined with DTP component vaccines to provide a multi-valent component vaccine without impairment of the immunogenic properties of the other antigens.

L'invention concerne une composition immunogène à multiconstituants assurant une protection sur un hôte immunisé contre l'infection causée par l'Hémophilus influenzae. Cette composition renferme au moins deux antigènes différents de Hémophilus influenzae, dont l'un est une adhésive. Les protéines de haut poids moléculaire (HMW) de Hémophilus influenzae dont le type ne peut être déterminé augmentent la réponse immunitaire d'un hôte à un analogue non protéolytique de la protéine Hin47 se trouvant dans ces compositions immunogènes dont un des constituants n'affecte par l'immmunogénicité de l'autre. Le vaccin Hémophilus peut être combiné avec des vaccins DCT afin d'obtenir un vaccin multivalent sans affecter les propriétés immunogènes des autres antigènes.

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