A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) C07K 7/00 (2006.01) C07K 14/47 (2006.01)
Patent
CA 2506328
Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise an HMGB A box, and/or an antibody preparation that specifically binds to an HMGB B box, and/or an inhibitor of TNF biological activity. The methods comprise treating a cell or a patient with sufficient amounts of the composition to inhibit the release of the proinflammatory cytokine, or to inhibit the inflammatory cytokine cascade.
L'invention concerne des compositions et des méthodes permettant d'inhiber, d'une part, la libération d'une cytokine proinflammatoire à partir d'une cellule et, d'autre part, une cascade de cytokine inflammatoire chez un patient. Ces compositions renferment une boîte A HMGB (<= high mobility group box >=) et/ou une préparation d'anticorps qui se lient spécifiquement à une boîte B HMGB, et/ou un inhibiteur de l'activité biologique du facteur de nécrose des tumeurs (TNF). Ces méthodes consistent à traiter une cellule ou un patient avec des quantités suffisantes de la composition pour inhiber la libération de la cytokine proinflammatoire ou la cascade de cytokine inflammatoire.
Newman Walter
O'keefe Theresa L.
Critical Therapeutics Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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