Glycoside-containing liposome

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/704 (2006.01) A61K 9/127 (2006.01) A61K 31/7032 (2006.01) A61K 47/18 (2006.01) A61K 47/24 (2006.01) A61P 35/00 (2006.01) C07H 15/10 (2006.01) C07H 15/18 (2006.01) C07J 17/00 (2006.01)

Patent

CA 2529992

A drug product which can maximize the effect of a cholestanol glycoside useful as an anticancer agent. The present invention provides a liposomal composition containing a glycoside exhibiting antitumor activity, a phospholipid, and a positive-charge-providing substance; the glycoside being composed of GlcNAc-Gal-, GlcNAc-Gal-Glc-, Fuc-Gal-, Gal-Glc-, or Gal- as a sugar moiety, and a hydrophobic compound capable of forming a liposome.

L'invention concerne une préparation médicale pouvant maximiser l'effet d'un glycoside cholestanol utile en tant qu'agent antitumoral. Il s'agit d'un liposome qui contient : un glycoside à composé hydrophobe comportant une activité antitumorale, qui contient du GlcNAc-Gal-, GlcNAc-Gal-Glc-, Fuc-Gal-, Gal-Glc ou Gal- en tant que sucre, et permettant de former un liposome; un phospholipide; et une substance offrant une charge positive.

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