Fgf-r4 receptor-specific antagonists

Details Fgf-r4 receptor-specific antagonists Fgf-r4 receptor-specific antagonists

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C12N 5/18 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2730300

The present invention relates to FGF-R4 receptor-specific antagonist molecules enabling the inhibition of the activity of said receptor. Said antagonists are, particularly, FGF-R4-specific antibodies enabling the inhibition of the activity of said receptor. The present invention also relates to the therapeutic use of said antibodies, particularly in the field of angiogenesis and in the treatment of certain types of cancer.

La présente invention a pour objet des molécules antagonistes spécifiques du récepteur FGF-R4 permettant d'inhiber l'activité de ce récepteur. Ces antagonistes sont en particulier des anticorps dirigés spécifiquement contre le récepteur FGF-R4 permettant d'inhiber l'activité de ce récepteur. La présente invention a également pour objet l'utilisation thérapeutique de ces anticorps, en particulier dans le domaine de l'angiogenèse, et dans le traitement de certains types de cancer.

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