Synthetic peptides and mixtures thereof for detecting hiv...

Details Synthetic peptides and mixtures thereof for detecting hiv... Synthetic peptides and mixtures thereof for detecting hiv...

C - Chemistry, Metallurgy

07

K

C07K 14/155 (2006.01) A61K 39/21 (2006.01) A61K 39/42 (2006.01) C07K 14/16 (2006.01) C07K 16/10 (2006.01) G01N 33/569 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2086922

There is provided cyclic peptides of general formulae (I) and (III), wherein x represents an amino acid sequence from posi- tion 585 to 604 (gp41-HIV-1) such amino acid sequences being characterized by at least one of a lysine at position 586 or a lysine at both positions 585 and 586; x2-represents an amino acid sequence from position 585 to 604 (gp41-HIV-1); y represents an amino acid sequence from position 612 to 629 (gp41-HIV-1); e and f represent one or more epitopes included in the amino acid sequence extending from 586 to 629 (gp4l-HIV-1) or from 578 to 613 (gp36- HIV-2); and a and b represent the amino and carboxy terminals, respectively, as well as substituents which are effective to make the peptide more useful as an immu- nodiagnostic reagent. Peptides of formula III have one or both of e and f present. There is also provided peptides of general formulae (II) and (IV), wherein x1 represents an amino acid sequence from position 577 to 596 (gp36-HIV-2) such amino acid sequences being characterized by at least one of a lysine at position 578 or a lysine at both positions 577 and 578; x3 represents an amino acid sequence from postion 577 to 596 (gp36-HIV-2); y1 represents an amino acid sequence from posi- tion 604 to 613 (gp36-HIV-2); e and f represents one or more epitopes included in the amino acid sequence from 578 to 613 (gp36-HIV-2) or 586 to 629 (gp41-HIV-1); and a and b ace as defined above. Peptides of formula (IV) have one or both of e and f present. These cyclic peptides alone or in admixture with other peptides are particularly useful in detecting HIV-1 and HIV-2 antibodies in analyzes and sera.

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