Apo-2 ligand

Details Apo-2 ligand Apo-2 ligand

C - Chemistry, Metallurgy

07

K

C07K 14/525 (2006.01) A01K 67/027 (2006.01) A61K 38/19 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C12N 5/16 (2006.01) C12N 15/19 (2006.01) C12N 15/28 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2666263

A cytokine, designated Apo-2 ligand, which induces mammalian cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and antibodies to Apo-2 ligand are also provided. Methods of using Apo-2 ligand to induce apoptosis and to treat pathological conditions such as cancer, are further provided.

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