Non peptide tachykinin receptor antagonists

Details Non peptide tachykinin receptor antagonists Non peptide tachykinin receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) A61K 31/343 (2006.01) A61K 31/405 (2006.01) C07D 209/20 (2006.01)

Patent

CA 2399584

Compounds of Formula (I) are specific tachykinin receptor antagonists where R, m, X, R1, R2, n, Y, R3, R4, R5, and R6 are as described in the specification. The compounds are useful agents for treating conditions associated with aberrant neovascularization such as rheumatoid arthritis, atherosclerosis and tumour cell growth.

La présente invention concerne des composés antagonistes de récepteur de tachykinine de formule (I), dans laquelle R, m, X, R1, R2, n, Y, R3, R4, R5 et R6 sont tels que décrits dans la description de l'invention. Ces composés sont des agents utiles pour traiter des états associés à une néovascularisation aberrante, telle que la polyarthrite rhumatoïde, l'athérosclérose et la croissance de cellules tumorales.

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