Peptides inhibiting il-1 beta release

Details Peptides inhibiting il-1 beta release Peptides inhibiting il-1 beta release

C - Chemistry, Metallurgy

07

K

C07K 5/10 (2006.01) A61K 38/04 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) C07K 5/08 (2006.01) C07K 5/083 (2006.01) C07K 14/545 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2116653

2116653 9309135 PCTABS00022 Di-, tri- and tetrapeptides in which the last .alpha.-amino acid is based on aspartic acid and attached to a residue A5 which is H; CF3; -Z1-Z2-Y2 wherein each of Z1 and Z2 independently is a direct bond or an .alpha.-amino acid residue and Y2 is NH2, C1-4 alkylamino, di-(C1-4 alkyl)amino or a heterocyclic radical attached by a nitrogen to Z2; -CH2-X1-Y3 wherein X1 is O or S and Y3 is heteroaryl; -CH2-Y3; substituted phenyl; ring substituted phenoxymethylene or phenylthiomethylene; ring substituted pyridyloxymethylene; or a radical -CH2-X1-CO-Y4 wherein X1 is O or S and Y4 is trialkylmethyl or substituted phenyl or pyridyl, in free form or in salt form, have pharmacological activity, e.g. IL-1.beta. release inhibiting properties.

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