Novel inhalation powder comprising the cgrp antagonist...

Details Novel inhalation powder comprising the cgrp antagonist... Novel inhalation powder comprising the cgrp antagonist...

A - Human Necessities

61

K

A61K 31/517 (2006.01) A61K 9/12 (2006.01) A61K 9/72 (2006.01)

Patent

CA 2536050

The invention relates to a powder preparation for pulmonary or nasal inhalation, comprising the CGRP antagonist 1-[N?2¿-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazine (A), or a pharmaceutically-acceptable salt thereof, methods for production and use thereof for the production of a medicament for the treatment of headaches, migraines and cluster headaches.

Compositions pulvérulentes pour l'inhalation pulmonaire ou nasale, qui contiennent l'antagoniste de CGRP 1-[<I>N</I>?2¿-[3,5-dibromo-<I>N</I>-[[4-(3,4-dihydro-2(1<I>H</I>)-oxoquinazolin-3-yl)-1-pipéridinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-pipérazine (A) ou un sel acceptable sur le plan pharmaceutique dudit composé. La présente invention concerne également des procédés de préparation desdites compositions ainsi que leur utilisation pour la fabrication d'un médicament destiné à traiter les céphalées, la migraine et l'algie vasculaire de la face.

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