C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01)
Patent
CA 2192820
This invention relates to compounds of formula (I), wherein A is N or -CT6; B is -NR1R2, -CR1R2R11, - C(=CR2R12)R1, -NHCHR1R2, - OCHR1R2, -SCHR1R2, - CHR2OR12, -CHR2SR12, -C(S)R1 or -C(O)R1. The compounds show corticotropin- releasing factor (CRF) antagonist activity. CFR antagonists are believed to be effective in the treatment of a wide range of stress-related illnesses, such as depression, anxiety, headache, irritable bowel syndrome, inflammatory diseases, immune suppressin, Alzheimer's disease, gastrointestinal diseases, anorexia nervosa, hemmorrhagic stress, drug and alcohol withdrawal symptoms, drug addiction and infertility.
L'invention porte sur des composés de formule (I) dans laquelle Areprésente N ou -CR¿6?; et B représente -NR¿1?R¿2?, -CR¿1?R¿2?R¿11?, -C(=CR¿2?R¿12?)R¿1?, -NHCHR¿1?R¿2?, -OCHR¿1?R¿2?, -SCHR¿1?R¿2?, -CHR¿2?OR¿12?, -CHR¿2?SR¿12?, -C(S)R¿1? ou -C(O)R¿1?. Lesdits composés qui présentent une activité antagoniste vis à vis du facteur de libération de la corticotropine (CRF) s'avèrent efficaces dans une grande plage de troubles liés au stress tels que la dépression, l'anxiété, les maux de tête, le syndrome d'irritation de l'intestin, les troubles de nature inflammatoire, l'immunodépression, la maladie d'Alzeimer, les troubles gastro-intestinaux, l'anorexie nerveuse, le stress hémorragique, les syndromes de sevrage alcoolique et toxicomaniaque, la toxicomanie et la stérilité.
Pfizer Inc.
Smart & Biggar
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