C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
C08B 37/00 (2006.01) A61K 31/715 (2006.01) A61K 47/48 (2006.01)
Patent
CA 2272362
Arabinogalactan compositions are provided which are useful in a wide variety of different biomedical applications. In one embodiment, water soluble lipidated arabinogalactans are provided which include arabinogalactan with a limited proportion of lipophilic groups, such as long-chain hydrocarbon groups, covalently attached to free hydroxyl groups on the arabinogalactan. The lipidated arabinogalactans are water soluble and biocompatible and are useful for a wide variety of different biomedical applications. The lipidated arabinogalactans can be used, for example, to inhibit cell adhesion, and to inhibit infection or inflammation. The lipidated arabinogalactans further may be used as adjuvants, to inhibit metastasis, and in other therapeutic applications.
Compositions d'arabinogalactane utiles dans un large éventail d'applications biomédicales. Un mode de réalisation porte sur des arabinogalactanes solubles à l'eau comprenant des lipides, qui se composent d'arabinogalactane comportant une proportion limitée de groupes lipophiles tels que des groupes hydrocarbures à chaîne longue, formant une liaison covalente avec des groupes hydroxyle libres sur l'arabinogalactane. Ces arabiogalactanes avec lipides sont solubles à l'eau et biocompatibles, et sont utiles pour un large éventail d'applications biomédicales diverses. Les arabinogalactanes avec lipides peuvent être utilisés par exemple pour inhiber l'adhésion cellulaire et pour inhiber l'infection ou l'inflammation. Ils peuvent en outre servir d'adjuvants dans les traitements visant à inhiber la formation de métastases et dans d'autres applications thérapeutiques.
Smart & Biggar
The University Of Montana
LandOfFree
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