Inhibitors of stat3

Details Inhibitors of stat3 Inhibitors of stat3

C - Chemistry, Metallurgy

07

F

C07F 9/6539 (2006.01) A61K 31/675 (2006.01) A61P 35/00 (2006.01) C07F 9/653 (2006.01)

Patent

CA 2737360

Disclosed herein are compounds derived from a chemical structure according to the formula (I) wherein X comprises oxygen or sulfur, R1 comprises a phenyl or naphthyl group, R2 comprises an amide group and R3 comprises a phosphate group. The disclosed compounds demonstrate inhibitory activity against STAT3, a protein found in certain tumor tissues and which promotes cellular overproliferation and resistance to apoptosis. The invention includes compositions containing the disclosed compounds, as well as methods of treatment therewith.

La présente invention concerne des composés dérivés dune structure chimique selon la formule (I) dans laquelle X comprend de loxygène ou du soufre, R1 comprend un phényle ou un groupe naphthyle, R2 comprend un groupe amide et R3 comprend un groupe phosphate. Les composés décrits présentent une activité inhibitrice contre la STAT3, une protéine trouvée dans certains tissus tumoraux et qui favorise la surprolifération cellulaire et la résistance à lapoptose. Linvention comprend également des compositions contenant les composés décrits, ainsi que des procédés de traitement les comprenant.

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