C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/87 (2006.01) A61K 47/30 (2006.01) A61K 48/00 (2006.01) C08L 75/02 (2006.01) C08L 75/04 (2006.01) C08L 77/12 (2006.01)
Patent
CA 2713185
The invention provides gene transfer compositions using as the gene carrier a biodegradable polymer that contains one or more cationic alpha amino acids, such as argininc or agmatine. The compositions form a tight soluble complex with a poly nucleic acid suitable for transfecting target cells to effect translation of the cargo poly nucleic acid by the target cell. Thus, such compounds are useful both in vitro and in vivo.
L'invention propose des compositions de transfert de gène qui utilisent comme porteur de gène un polymère biodégradable qui contient un ou plusieurs acides alpha-aminés cationiques, tels que l'arginine ou l'agmatine. Les compositions forment un complexe soluble serré avec un poly(acide nucléique) approprié pour transfecter des cellules cibles afin d'effectuer une traduction du poly(acide nucléique) de cargaison par la cellule cible. Ainsi, de tels composés sont utiles à la fois in vitro et in vivo.
Chantung Ronald Lee
Cruz-Aranda Gina Ann
Defife Kristin M.
Gomurashvili Zaza D.
Turnell William G.
Medivas Llc
Smart & Biggar
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