Recombinant defective adenoviruses expressing cytokines for...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/86 (2006.01) A61K 35/12 (2006.01) A61K 35/76 (2006.01) A61K 48/00 (2006.01) C07K 14/52 (2006.01) C12N 5/10 (2006.01) C12N 15/19 (2006.01) C12N 15/861 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2102302

L'invention concerne un acide nucléi- que recombinant utilisable pour la produc- tion d'un adénovirus défectif contenant un in- sérat codant pour une cytokine sous le contrô- le d'un promoteur au sein de la séquence gé- nomique de l'adénovirus recombinant. Cet adénovirus recombinant est utilisable pour la préparation de médicaments anti-tumoraux sous forme directement injectable dans la tu- meur de l'hôte.

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