C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/24 (2006.01) A61P 37/02 (2006.01) A61P 37/08 (2006.01)
Patent
CA 2571799
The present invention concerns immunoglobulins, particularly antibodies which specifically bind human Interleukin 13 (hIL-13). Antibodies of the invention may be used in the treatment of a variety of diseases or disorders responsive to modulation of the interaction between hIL-13 and the human IL-13 receptor. Such diseases include severe asthma, atopic dermatitis, COPD and various fibrotic diseases. Pharmaceutical compositions comprising said antibodies and methods of manufacture are also disclosed.
La présente invention concerne des immunoglobulines, en particulier des anticorps qui se lient spécifiquement à l'interleukine 13 humaine (hIL-13). Les anticorps selon l'invention peuvent être utilisé dans le traitement d'une variété de maladies ou de troubles sensibles à une modulation de l'interaction entre l'hIL-13 et le récepteur de l'IL-13 humaine. Lesdites maladies comprennent l'asthme sévère, la dermatite atopique, la BPCO et diverses maladies fibrotiques. L'invention concerne également des compositions pharmaceutiques comprenant lesdits anticorps ainsi que des méthodes de fabrication.
Ashman Claire
Cassidy Martin John
Ellis Jonathan Henry
Wattam Trevor Anthony Kenneth
Glaxo Group Limited
Gowling Lafleur Henderson Llp
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