Synthetic human genes and polypeptides and their use in the...

Details Synthetic human genes and polypeptides and their use in the... Synthetic human genes and polypeptides and their use in the...

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C12N 15/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2404438

Synthetic human target autoantigen genes comprising sequences coding for at least two immunogenic epitopic clus ters thereinafter IEC) of autoantigen(s) related to a specific autoimmune disease, wherein said at least two IECs may be derived from a sole autoantigen or from at least two different autoantigens related to said autoimmune disease, and polypeptides encoded thereby, can be used for the treatment and the diagnosis of autoimmune diseases such as multiple sclerosis (MS), insulin dependent diabetes mellitus (IDDM), rheumatoid arthritis (RA), myasthenia gravis (MG) and uveitis.

L'invention concerne des auto-antigènes cible humains synthétiques contenant des séquences codant pour au moins deux batteries épitopes immunogènes (ici après IEC) d'auto-antigènes liés à une maladie auto-immune spécifique, ces batteries IEC pouvant être dérivées à partir d'un auto-antigène unique ou à partir d'au moins deux auto-antigènes différents, liés à la maladie auto-immune, ainsi que les polypeptides codés, pouvant s'utiliser dans le traitement et le diagnostic de maladies auto-immunes telles que la sclérose en plaques, le diabète insulino-dépendant, l'arthrite rhumatoïde, la myasthénie et l'uvéite.

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