Enantioselective hydrolysis of ketoprofen esters by...

Details Enantioselective hydrolysis of ketoprofen esters by... Enantioselective hydrolysis of ketoprofen esters by...

C - Chemistry, Metallurgy

12

P

C12P 41/00 (2006.01) C12P 7/40 (2006.01) C12P 13/00 (2006.01)

Patent

CA 2157799

A process for producing substantially pure R-Ketoprofen by the enantioselective hydrolysis of racemic Ketoprofen choline ester is disclosed. The process utilizes either intact Beauveria bassiana hyphae or an R-specific ester hydrolase isolated therefrom. The ester hydrolase has an approximate molecular weight of 17,800 daltons and an N-terminal sequence of Ala-Pro-Asp-W-IIe-IIe-Gln-Gly-Leu-Ser- Arg-Ala-X-Asp-Gly-Gln-Asp.

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