Phenyl substituted cycloalkyl hydroxyurea derivatives which...

Details Phenyl substituted cycloalkyl hydroxyurea derivatives which... Phenyl substituted cycloalkyl hydroxyurea derivatives which...

C - Chemistry, Metallurgy

07

C

C07C 323/47 (2006.01) A61K 31/17 (2006.01) C07C 275/64 (2006.01)

Patent

CA 2133218

Certain novel phenylsubstituted cycloalkylurea compounds having the ability to inhibit the enzyme 5-lipoxygenase and having formula (I); wherein A is C1-C4 alkylene or C2-C6 alkenylene; each B is independently halogen, C1-C4 alkyl, C2-C8 alkoxyalkyl or halosubstituted C1-C4 alkyl; X is methylene or ethylene; M is hydrogen or a pharmaceutically acceptable ca- tion; A r is phenyl or mono-, di- or tri-substituted phenyl wherein the substituents are each independently selected from ha- logen, C1-C4 alkyl, C1-C4 alkoxy, halosubstituted C1-C4 alkyl, (C1-C4 alkyl)phenoxy, (C1-C4 alkoxy)phenoxy, halosubstitut- ed phenoxy, halosubstituted (C1-C4 alkyl)phenoxy, phenylthio, (C1-C4 alkyl)phenylthio, (C1-C4 alkoxy)phenylthio, halosub- stituted phenylthio and halosubstituted (C1-C4 alkyl)phenylthio; A, B and Ar may be attached at any available position on the ring; m is 0 or 1; and n is 0, 1 or 2. These compounds are useful in the treatment or alleviation of inflammatory diseases, allergic conditions and cardiovascular diseases in mammals and as the active ingredient in pharmaceutical compositions for treating such conditions.

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