C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 17/16 (2006.01) A23L 1/275 (2006.01) A61K 8/72 (2006.01) A61K 31/785 (2006.01) A61K 35/36 (2006.01) A61Q 17/04 (2006.01) C03C 4/02 (2006.01) C09B 59/00 (2006.01) C09B 67/00 (2006.01) C09B 69/10 (2006.01) C09D 5/32 (2006.01) C12P 17/00 (2006.01) C12P 17/10 (2006.01) D06P 3/02 (2006.01) A61K 7/06 (1990.01) A61K 7/13 (1990.01) A61K 7/42 (1990.01)
Patent
CA 2092205
2092205 9216189 PCTABS00016 A melanin that is soluble in an aqueous solution at a pH of at lest 5 to 9 at a temperature of 0 to 100 ·C. The melanin is further characterized by being capable of being filtered through at least a 0.45 micron size filter. Still further, the melanin is characterized by having a molecular weight of greater than 10,000 kilodaltons. The melanin is useful for providing a naturally-appearing tan to mammalian skin and hair. Such melanin can be produced by combining dopachrome and 5,6-dihydroxyindole (or allowing dopachrome to spontaneously form 5,6-dihydroxyindole) and an appropriate enzyme or by combining 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid or by incubating 5,6-dihydroxyindole-2-carboxylic acid alone. The melanin is also useful for providing a sun-screen to mammalian skin and hair, to treat post-inflammatory hypo- and hyperpigmentation, to tint glass and plastic, to protect industrial materials against ultraviolet damage, and as a coloring agent in foodstuffs such as coffee, tea, soda, whiskey and liquors.
Orlow Seth J.
Pawelek John M.
Borden Ladner Gervais Llp
Yale University
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