A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 31/216 (2006.01)
Patent
CA 2703598
Solid oral dosage forms, especially tablets, of a pharmaceutical composition comprising a supramolecular complex can be formed from a direct compression process or a compaction process such as roller compaction. Such solid oral dosage forms feature an immediate release profile that allows for fast release of the therapeutic agent. A particularly useful supramolecular complex is trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3- ethoxycarbonyl-l-butylcarbamoyl) propionate-(S)-3'-methyl-2'-(pentanoyl {2"-(tetrazol-5-ylate)biphenyl-4'- ylmethyl } amino)butyrate]hemipentahydrate.
L'invention concerne des formes de dosage orales solides, en particulier des comprimés, d'une composition pharmaceutique comprenant un complexe supramoléculaire, lesquelles formes peuvent être formées par un procédé de compression directe ou un procédé de compactage, comme un compactage par rouleaux. De telles formes de dosage orales solides présentent un profil de libération immédiate qui permet une libération rapide de l'agent thérapeutique. Un complexe supramoléculaire particulièrement utile est le trisodium[3-((1S,3R)-1-biphényl-4-yl-méthyl-3-éthoxycarbonyl-1-butylcarbamoyl)propionate-(S)-3'-méthyl-2'-(pentanoyl{2'-(tétrazol-5-ylate)biphényl-4'-yl-méthyl}amino)butyrate]hémipentahydrate.
Al-Fayoumi Suliman
Hu Jiahui
Kumaraperumal Natrajan
Royce Alan Edward
Ruegger Colleen
Fetherstonhaugh & Co.
Novartis Ag
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