A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/10 (2006.01) A61K 9/08 (2006.01) A61K 45/06 (2006.01) A61K 51/00 (2006.01) A61M 36/14 (2006.01)
Patent
CA 2315092
Disclosed are compositions and methods for the facile perfusion of a tissue with active agents following direct intra-tissue injection. Targets may consist of cells, cellular components, and/or extracellular components. The high perfusion efficiency permits high concentrations of active agents to be delivered to tissue targets resulting in high degrees of efficacy and in some instances the production of novel pharmacological activities of an active agent previously unknown or previously unattainable in vivo.
L'invention concerne des compositions et des procédés facilitant la perfusion d'agents actifs dans un tissu à la suite d'une injection intra-tissulaire directe. Les cibles peuvent être constituées par des cellules, des composants cellulaires, et/ou des composants extra-cellulaires. L'efficacité élevée de cette perfusion permet l'injection d'agents actifs hautement concentrés dans des cibles tissulaires, ce qui permet d'obtenir un degré élevé d'efficacité et, dans certains cas, certaines nouvelles activités pharmacologiques d'un agent actif, activités jusqu'alors inconnues ou impossibles à obtenir in vivo.
Decrescito Vincent
Kronenthal Richard
Mcbeth Dean
Pietronigro Dennis
Direct Therapeutics Inc.
Robic
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