Therapeutic use of an inhibitor of a hedgehog or a...

A - Human Necessities – 61 – K

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A61K 38/17 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 11/00 (2006.01) A61P 13/12 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 14/47 (2006.01) C12N 15/63 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2376210

Use of an inhibitor of a Hedgehog signalling pathway, or an inhibitor of a pathway which is a target of the Hedgehog signalling pathway in the preparation of a medicament for treatment of epithelial cell hyperplasia, fibrosis of tissue, inflammation, cancer or an immune disorder. Also a transgenic animal or cell line capable of expressing a component or an inhibitor of a hedgehog signalling pathway or a target pathway of the hedgehog signalling pathway.

Utilisation d'un inhibiteur du trajet de signalisation du hérisson ou d'un inhibiteur d'un trajet représentant une cible du trajet de signalisation du hérisson dans le but de préparer un médicament servant à traiter l'hyperplasie des cellules épithéliales, la fibrose des tissus, l'inflammation, le cancer ou une maladie immune. Egalement, animal transgénique ou lignée cellulaire capables d'exprimer un élément ou un inhibiteur d'un trajet de signalisation du hérisson ou d'un trajet représentant une cible du trajet de signalisation du hérisson.

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