C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) C07K 16/18 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2445253
The present invention relates to a method for the generation of single chain immunoglobulins in a mammal. In particular, the present invention relates to a method for the generation of single chain camelid VHH antibodies in a mammal which undergo the process of class-switching and affinity maturation found within antibody producing B cells. Single chain antibodies generated using the method of the present invention and the uses thereof are also described.
L'invention concerne un procédé permettant la production d'immunoglobulines monocaténaires par un mammifère. L'invention concerne en particulier un procédé permettant la génération d'anticorps monocaténaires de camélidés par un mammifère, lesquels subissent le processus de commutation isotypique et de maturation d'affinité qu'on trouve dans les lymphocytes B producteurs d'anticorps. L'invention concerne également les anticorps monocaténaires générés au moyen de ce procédé ainsi que leurs utilisations.
Erasmus Universiteit Rotterdam
Mbm Intellectual Property Law Llp
LandOfFree
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