C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07F 5/02 (2006.01) C07H 13/04 (2006.01) C07H 19/10 (2006.01) C07H 21/00 (2006.01) C07K 2/00 (2006.01) C07K 14/00 (2006.01) C07K 16/00 (2006.01) C09B 57/00 (2006.01) C09K 11/06 (2006.01) G01N 33/532 (2006.01) G01N 33/533 (2006.01) G01N 33/58 (2006.01)
Patent
CA 2122627
This invention relates to derivatives of dipyrrometheneboron difluoride fluorescent dyes that have an absorption maximum at wavelengths longer than about 525 nm, and are chemically reactive with nucleic acids, proteins, carbohydrates, and other bio- logically derived or synthetic chemical materials. The dyes generally have structure (I), wherein at least one of the substituents R1-R7, is a reactive functional group, and at least one of the substituents R1- R7 contains a bathochromic moiety. The ba- thochromic moiety is an unsaturated organic group, preferably heteroaryl or alkenyl. The remaining substituents, which may be the same or different, are hydrogen, halogen, alkyl (containing 1-5 carbon atoms), aryl, arylalkyl, or sulfo. The dyes are used to make novel conjugates with members of specific binding pairs that are ligands or receptors.
Haugland Richard P.
Kang Hee C.
Mbm Intellectual Property Law Llp
Molecular Probes Inc.
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